Motif ID: FOX{D1,D2}.p2

Z-value: 1.572


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2



Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_14985272 2.210 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr11_-_85074848 2.113 NM_152723
CCDC89
coiled-coil domain containing 89
chr18_+_64616296 1.883 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr3_+_189413414 1.810 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_159459814 1.809 APOA2
apolipoprotein A-II
chr16_+_54070302 1.790 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr3_-_71376919 1.735 FOXP1
forkhead box P1
chr11_-_114880275 1.729 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr10_-_101831579 1.726 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr10_+_104525877 1.696 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr5_-_42847716 1.685 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr13_+_112825113 1.640 NM_000504
F10
coagulation factor X
chr1_-_159459999 1.639 NM_001643
APOA2
apolipoprotein A-II
chr1_-_20682541 1.626


chr16_-_85099941 1.529 LOC400550
hypothetical LOC400550
chr9_+_117955890 1.488 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_+_134483305 1.419 NM_018295
TMEM140
transmembrane protein 140
chr8_+_40130143 1.399 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr17_+_9686572 1.348 GLP2R
glucagon-like peptide 2 receptor
chr12_+_119900931 1.324 NM_000545
HNF1A
HNF1 homeobox A
chr1_-_199732323 1.321 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr3_-_58497913 1.320 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr3_-_115825742 1.273 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_154072654 1.265 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr7_-_139987044 1.255 DENND2A
DENN/MADD domain containing 2A
chr7_+_1543644 1.248 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr7_-_95063738 1.197 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr2_-_233586145 1.193 NGEF
neuronal guanine nucleotide exchange factor
chr1_-_24342158 1.172 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr2_-_233586164 1.167 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr11_+_73037382 1.162 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_116455898 1.143 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr12_+_119900677 1.116 HNF1A
HNF1 homeobox A
chr16_-_56389176 1.104 NM_001130099
KIFC3
kinesin family member C3
chr17_-_6958695 1.102 ASGR2
asialoglycoprotein receptor 2
chr10_-_105411339 1.090 SH3PXD2A
SH3 and PX domains 2A
chr4_+_15038726 1.059 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr18_-_490583 1.041 NM_130386
COLEC12
collectin sub-family member 12
chr11_+_101488380 1.016 NM_001195045
YAP1
Yes-associated protein 1
chr2_+_73973640 0.990 ACTG2
actin, gamma 2, smooth muscle, enteric
chr14_-_22358752 0.984 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr20_-_49612574 0.983 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr14_+_23937766 0.982 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_-_134042500 0.981 NM_207363
NM_207481
NCKAP5

NCK-associated protein 5

chr2_-_192420168 0.981 NM_004657
SDPR
serum deprivation response
chr20_-_49612745 0.969 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr3_-_52844274 0.963 NM_205853
MUSTN1
musculoskeletal, embryonic nuclear protein 1
chr2_-_165259334 0.958 COBLL1
COBL-like 1
chr1_-_112333192 0.956 NM_004980
NM_172198
KCND3

potassium voltage-gated channel, Shal-related subfamily, member 3

chr1_+_84402962 0.953 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_73973600 0.953 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr10_+_63478974 0.949 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_-_30151526 0.940 NM_170769
NM_025236
RNF39

ring finger protein 39

chr22_-_30018329 0.928 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr22_-_35835548 0.916 TMPRSS6
transmembrane protease, serine 6
chr12_-_9159707 0.914 A2M
alpha-2-macroglobulin
chr17_-_6958773 0.913 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr11_+_834445 0.898 NM_001025237
TSPAN4
tetraspanin 4
chr13_-_37341859 0.897 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr16_+_66129481 0.887 FAM65A
family with sequence similarity 65, member A
chr6_+_62341966 0.884 NM_001190706
MTRNR2L9
MT-RNR2-like 9
chr2_-_192419896 0.882 SDPR
serum deprivation response
chr12_-_9159780 0.872 A2M
alpha-2-macroglobulin
chr12_+_32578513 0.846 FGD4
FYVE, RhoGEF and PH domain containing 4
chr12_-_9159742 0.836 A2M
alpha-2-macroglobulin
chr7_+_113513828 0.836 FOXP2
forkhead box P2
chr7_+_116238309 0.829 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr1_-_20685314 0.814 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_-_71196696 0.813 FOXP1
forkhead box P1
chr20_-_49818268 0.810 ATP9A
ATPase, class II, type 9A
chr12_+_99391681 0.782 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr20_+_43468617 0.776 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr3_+_64645819 0.776 LOC100507098
hypothetical LOC100507098
chr3_-_114643008 0.769 NM_001164496
NM_018338
WDR52

WD repeat domain 52

chr1_-_75854281 0.768 SLC44A5
solute carrier family 44, member 5
chr20_+_44771532 0.767 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr20_-_49818306 0.766 NM_006045
ATP9A
ATPase, class II, type 9A
chr7_+_113513600 0.765 FOXP2
forkhead box P2
chr17_-_61655915 0.762 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr18_+_30544193 0.759 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr11_+_62893836 0.754 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr12_+_99391870 0.750 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr11_-_34491878 0.747 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr12_-_9159789 0.746 NM_000014
A2M
alpha-2-macroglobulin
chr16_-_28457728 0.743 NUPR1
nuclear protein, transcriptional regulator, 1
chr4_-_186693574 0.740 NM_001114107
NM_014476
PDLIM3

PDZ and LIM domain 3

chr15_-_81037554 0.733 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr2_+_176761552 0.732 NM_024501
HOXD1
homeobox D1
chr2_-_165133239 0.730 GRB14
growth factor receptor-bound protein 14
chr2_-_68400516 0.728 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr10_+_18729518 0.728 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_-_92124064 0.727 TGFBR3
transforming growth factor, beta receptor III
chr3_+_139636104 0.721 NM_031913
ESYT3
extended synaptotagmin-like protein 3
chr6_-_87861492 0.715 NM_000735
CGA
glycoprotein hormones, alpha polypeptide
chr17_-_43390108 0.710 NM_024320
PRR15L
proline rich 15-like
chr6_-_127822227 0.709 NM_014702
KIAA0408
KIAA0408
chr1_-_27113018 0.698 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_-_1346465 0.675 NM_001145210
LOC441869
hypothetical protein LOC441869
chr14_+_22136968 0.669 NM_022060
ABHD4
abhydrolase domain containing 4
chr3_+_139636111 0.668 ESYT3
extended synaptotagmin-like protein 3
chr7_+_94377145 0.665 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr7_+_113842470 0.658 FOXP2
forkhead box P2
chr15_-_68781662 0.650 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_-_188086612 0.635 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr10_+_123913094 0.634 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr8_+_67096344 0.632 NM_033105
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr7_+_136203938 0.625 NM_001006627
NM_001006630
CHRM2

cholinergic receptor, muscarinic 2

chr9_+_27099138 0.612 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr17_-_36418869 0.610 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr17_+_2627099 0.606 RAP1GAP2
RAP1 GTPase activating protein 2
chr1_+_183970093 0.605 NM_031935
HMCN1
hemicentin 1
chr10_+_31650069 0.602 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr11_+_22652894 0.598 NM_005256
GAS2
growth arrest-specific 2
chr16_-_65742323 0.595 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr17_+_56109940 0.592 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr3_+_173043832 0.581 NM_001164436
TMEM212
transmembrane protein 212
chr9_+_133154896 0.580 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr9_+_139245029 0.579 NM_001177316
NM_001177317
SLC34A3

solute carrier family 34 (sodium phosphate), member 3

chr5_-_121842680 0.577


chr7_-_81237162 0.574 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr10_-_92671005 0.572 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr12_-_90100733 0.571 NM_001920
DCN
decorin
chr3_+_171621721 0.569 NM_001185056
CLDN11
claudin 11
chr11_-_76676110 0.568 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr3_-_55489973 0.565 WNT5A
wingless-type MMTV integration site family, member 5A
chr11_+_22652957 0.563 GAS2
growth arrest-specific 2
chr1_-_60164912 0.563 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr10_-_44794146 0.554 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr21_-_38955487 0.550 NM_001136154
NM_004449
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr19_+_40322231 0.532 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_210726539 0.529 C2orf67
chromosome 2 open reading frame 67
chr4_+_187424336 0.524 F11
coagulation factor XI
chr7_+_28415495 0.523 LOC401317
hypothetical LOC401317
chr19_+_46417099 0.522 AXL
AXL receptor tyrosine kinase
chr13_-_109600709 0.520 COL4A1
collagen, type IV, alpha 1
chr9_+_139245197 0.520 NM_080877
SLC34A3
solute carrier family 34 (sodium phosphate), member 3
chr6_+_32229599 0.517 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr19_+_46417117 0.514 AXL
AXL receptor tyrosine kinase
chr14_-_23653965 0.502 NRL
neural retina leucine zipper
chr14_-_93859394 0.500 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr5_-_44424423 0.499 NM_004465
FGF10
fibroblast growth factor 10
chr1_-_238842011 0.495 GREM2
gremlin 2
chr4_+_120167264 0.492 SYNPO2
synaptopodin 2
chr9_-_14900992 0.490 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr6_+_32229771 0.488 PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr2_-_101457596 0.488 NM_001145664
RFX8
regulatory factor X, 8
chr10_-_54201400 0.486 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr19_-_7244876 0.486 NM_000208
NM_001079817
INSR

insulin receptor

chr7_-_27149750 0.483 NM_019102
HOXA5
homeobox A5
chr14_+_23654161 0.480 DCAF11
DDB1 and CUL4 associated factor 11
chr19_+_46416938 0.478 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr10_-_92670764 0.478 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_107508040 0.476 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr14_+_23653848 0.476 DCAF11
DDB1 and CUL4 associated factor 11
chr4_+_120167770 0.474 SYNPO2
synaptopodin 2
chr10_+_123912930 0.471 TACC2
transforming, acidic coiled-coil containing protein 2
chr4_+_39084867 0.469 NM_175737
KLB
klotho beta
chr16_-_28457825 0.465 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr14_+_23653819 0.464 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr14_-_75517198 0.461 TGFB3
transforming growth factor, beta 3
chr2_-_188127294 0.460 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_+_203064397 0.457 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr1_-_238842071 0.456 NM_022469
GREM2
gremlin 2
chr3_-_127719283 0.455 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chr8_-_93144366 0.455 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_-_50596238 0.450 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr21_-_34820916 0.450 NM_203418
RCAN1
regulator of calcineurin 1
chr19_+_46416971 0.447 AXL
AXL receptor tyrosine kinase
chr1_-_34403443 0.444 CSMD2
CUB and Sushi multiple domains 2
chr12_-_90100710 0.443 DCN
decorin
chr17_+_69939130 0.441 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr10_-_52315390 0.439 A1CF
APOBEC1 complementation factor
chr20_+_31059174 0.439 BPIL1
bactericidal/permeability-increasing protein-like 1
chr2_-_189752575 0.435 NM_000393
COL5A2
collagen, type V, alpha 2
chr4_+_71126376 0.432 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr2_+_109909139 0.431 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr19_+_46416975 0.429 AXL
AXL receptor tyrosine kinase
chr1_-_31618405 0.428 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr12_-_51629874 0.425 KRT8
keratin 8
chr15_-_58671929 0.422 NM_134262
RORA
RAR-related orphan receptor A
chr7_+_134114957 0.421 CALD1
caldesmon 1
chr1_-_60165049 0.419 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr14_+_23653745 0.419 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr1_-_177378801 0.417 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr14_+_55654900 0.416 PELI2
pellino homolog 2 (Drosophila)
chr12_-_90100679 0.414 DCN
decorin
chr17_+_64922420 0.410 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chrX_+_49718954 0.408 NM_000084
CLCN5
chloride channel 5
chr8_-_134378630 0.405 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr11_-_10630408 0.404 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr16_+_52027020 0.403 RBL2
retinoblastoma-like 2 (p130)
chr12_+_120055013 0.402 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr22_+_36286350 0.402 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr1_-_92124201 0.402 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr6_+_84619703 0.400 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr2_-_180319013 0.397 NM_001113397
ZNF385B
zinc finger protein 385B
chr16_+_68516401 0.397 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr17_+_54763689 0.393 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr20_+_42777298 0.391 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr20_+_254205 0.391 NM_006943
SOX12
SRY (sex determining region Y)-box 12

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.55 2.50e-02 GO:0043408 regulation of MAPKKK cascade
1.96 3.92e-02 GO:0032583 regulation of gene-specific transcription
1.22 4.23e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.76 4.36e-02 GO:0031983 vesicle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.82 4.97e-02 GO:0019838 growth factor binding